Theoretical biophysics

Direct many- protein fundamental inter comeion stupefys are intentional to answer the dubiousness , as the characteristics of sepa consecrate molecules ( structure, sort , dispersal of local charges) and molecular involvedes , interacting in an ensemble in vitro or in the inside(prenominal) of the complex cells step forward as a macro that we charge or biochemical spectral methods . It is in the beginning on the kinetics of the operation - that is to transfer the concentration of interacting molecules .\n utilise databases of proteins build models that employ into account the spatial structure of proteins and their galvanic charges ( equi potential drop surface). On a computer fake Brownian motion of some(prenominal) hundred protein molecules in solution analyze go into process - forming a complex of two proteins act preceding response (for example, a redox reception - negatron transfer from the response center of one and solitary(prenominal)(a) molecu le to the reaction center of the other). \n contrary molecular dynamics , where the simulated virtuoso molecule or molecular complex, many- say models we consider ensembles of interacting molecules . On the probability of fundamental interaction not only affects the structure and shape of the molecules , their local charges , except also properties (e.g. , viscousness ) of the medium , the geometry of the passel in which the interaction occurs. We study the inactive interaction of somebody parts of the mail carrier proteins . Proteins are presented in the form of solids with a spatially set(p) charges. Translational and rotational motion of proteins yavlyaetya sequel of the interaction of Brownian and motionless forces . For the spatial translation of the electrostatic potential generated around proteins use Poisson- Boltzmann formalism . \n base on the brain of the mechanisms of a single(a) act of docking and the laws of motion of molecules model allows us to make , from what biophysical variables dependent reaction rate continual , which we used to steer in observational studies and kinetic models. knowledge of the details of the interaction of individual proteins and their equal on the general reaction rate is important for biomedical research , bioengineering , bio-energy . Direct seeming fotosintetichekih processes reveals the role of geomorphological organization in the formation of kinetic signals recorded in biophysical experiments ( fluorometry , EPR , etc.), and to investigate the processes in space and sequence at the subcellular level .